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East Harrisburg is a conglomeration of neighbourhoods in the eastern end of the U.S. city of Harrisburg, Pennsylvania. Its zip codes are 17103, 17104, and 17105. Its southern border is formed by Interstate 83; eastern border is the Capital Area Greenbelt; northern border is the borough of Penbrook and Susquehanna Township; western border is the Allison Hill neighborhood.

The neighboring Borough of Penbrook was once officially named East Harrisburg. It still maintains a Harrisburg postal zip code.